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KMID : 1155520070020030151
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Anesthesia and Pain Medicine
2007 Volume.2 No. 3 p.151 ~ p.155
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Effect of N-acetyl-cysteine on Allodynia in a Chronic Post-ischemia Pain Model of Rat
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Ha In-Ho
Han Chnag-Gyu
Kwak Kyung-Hwa
Jeon Young-Hun
Park Sung-Sik
Hong Jung-Gil
Lim Dong-Gun
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Abstract
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Background: Complex regional pain syndrome type I (CRPS-I) is a clinical syndrome that is poorly understood and difficult to treat. Reactive oxygen species (ROS) and inflammatory responses may contribute to the development of CRPS-I. This study evaluated the effect of N-acetyl-cysteine (NAC) on both mechanical and cold allodynia in a rat CRPS-I model.
Methods: Male adult SD rats were used for the CRPS-I model that was produced following prolonged hindpaw ischemia/reperfusion. The rats were divided into 3 groups, Group O (-) (n = 8): rats without a tourniquet; Group O (+) (n = 8): rats received ischemic injury with a tourniquet on the hindpaw and they were reperfused 3 hours after the tourniquet application; and Group ON (+) (n = 8): rats received ischemic injury with a tourniquet ring on the hindpaw and they were reperfused 3 hours after the tourniquet application and they received intraperitoneal N-cetyl-ysteine (500 mg/kg) injection just after the tourniquet application and at 1 day and 2 days after the reperfusion.
Results: In the Group O (+), mechanical (von Frey hair) and cold (acetone exposure) allodynia were evident in the affected hindpaw as early as 1 day after reperfusion; this was extended for 2 weeks and it spread to the uninjured contralateral hindpaw. In the Group ON (+), the mechanical and cold allodynia were attenuated compared to those rats of Group O (+).
Conslusions: NAC, a free radical scavenger, was able to reduce mechanical and cold allodynia in this model, and the generation of ROS is partly responsible for CRPS-I.
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KEYWORD
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allodynia, complex regional pain syndrome type I, N-acetyl-cysteine
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